Fig. 5: Dimer formation of MCT8. | Nature Communications

Fig. 5: Dimer formation of MCT8.

From: Structural insights into thyroid hormone transporter MCT8

Fig. 5

Monomeric MCT8 in the membrane. The hydrophilic cluster (highlighted in green), formed by His186, Ser189, Thr268, and Ser267, is not favored within the hydrophobic membrane environment. Hydrophobic cluster is colored yellow. Dimeric MCT8 in the membrane. Lipid binding promotes MCT8 dimerization, which buries the hydrophilic cluster. Lipid-like compounds (highlighted in red) have the potential to act as molecular glues, facilitating MCT8 dimer formation.

Back to article page