Fig. 7: Protein-lipid phase coupling in the ANXA11-lysosome ensemble.
From: ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
The ARD of ANXA11 mediates binding to lysosomes in a Ca2+-dependent manner and causes a phase transition in lysosomal membrane lipids into a more ordered state. Condensation of the ANXA11 LCD can then act to tune the magnitude of this lipid phase transition in a coupled manner. ANXA11 interacting partners ALG2 and CALC either increase (ALG2) or decrease (CALC) ANXA11 LCD-based condensation to regulate phase coupled effects on lysosomal membrane lipids.
