Fig. 5: Single‑cell transcriptome atlas of HF cells from murine dorsal skin at early depilation‑induced anagen.

A UMAP representation of all HF cells in the murine dorsal skin across six time points at the early anagen stages of hair regeneration after depilation, colored according to the main cell classes. The plot was generated by integration of 1732, 1627, 2342, 2500, 6322 and 4433 cells for 0 h, 4 h, 16 h, 2 d, 4 d and 6 d post‑depilation, respectively. B Dot plot of marker genes used for annotation of cell clusters in (A). The colour scales correspond to the averaged expression levels. The dot size corresponds to the ratio of cells expressing the gene in the cell type. C Heatmap of top 10 marker genes for each cell cluster in (A). D UMAP visualization of HF cells in each time point post‑depilation as indicated. E Number of differentially expressed (DE) genes for each cell type during hair regeneration along the time course. F A heatmap showing the upregulated and downregulated DE genes in the p53 signaling, mismatch repair and cell cycle pathways in cells from the OB1 and cycling_OB1 clusters over the course of hair regeneration.