Fig. 4: Predicted biological functions and upstream regulators across WD/Ext conditions and NAc-subregions. | Nature Communications

Fig. 4: Predicted biological functions and upstream regulators across WD/Ext conditions and NAc-subregions.

From: Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens in male rats

Fig. 4

A Top gene ontology (GO) terms in NAc-core featured enrichment of DEGs associated with growth factors, integrins regulation (Ctx) and RNA biosynthesis (HC and Ext), while NAc-shell was implicated in cell division, DNA replication, receptor signaling/transactivation (Ctx and HC) and extracellular matrix dynamics (Ext). Dot size is reflective of the number of genes per gene ontology term. B Venn diagrams highlighting different GO term distribution across conditions with the Ext group involving a higher number of biological functions. C Upstream regulator analysis linked numerous putative regulators to the seeded DEGs with activation or suppressive properties across the WD/Ext conditions in NAc-core or shell. Activation z scores: Activated (yellow) = overrepresentation of targets activated by the regulator; Suppressed (blue) = overrepresentation of targets repressed by the regulator; black/gray = not a predicted upstream regulator.

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