Fig. 5: Motif enrichment analysis and identification of DNA binding factors across WD/Ext conditions and NAc-subregions. | Nature Communications

Fig. 5: Motif enrichment analysis and identification of DNA binding factors across WD/Ext conditions and NAc-subregions.

From: Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens in male rats

Fig. 5

A Top transcription factors deduced (seeded) across WD/Ext conditions and NAc-subregions obtained by Simple Enrichment Analysis (SEA) of DEGs. The identified motifs were overwhelmingly linked to putative factors in the Ctx group within NAc-core, while elevated incidences in NAc-shell were observed for the Ext group. The Q-value represents the minimum false discovery rate (FDR) required to consider a motif significant. B Representation of selected (top) individual motifs (logos, positions and incidence/matches) and their binding factors. Positional distribution of the best match to the motif in the primary sequences. The dotted line indicated the position of the sequences aligned to the left/right ends or centers. The histograms show the number of motif matches in the primary sequence with at least one match.

Back to article page