Fig. 6: Co-expression network analysis across WD/Ext conditions and NAc-subregions. | Nature Communications

Fig. 6: Co-expression network analysis across WD/Ext conditions and NAc-subregions.

From: Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens in male rats

Fig. 6

A Sunburst plots, depicting gene (DEGs) co-expression networks by MEGENA in cocaine-exposed groups, show little overlap (white/blue modules) when the Ctx group is compared with the HC or Ext groups (core/shell; left and middle panels). Still, the presence of overlapping gene modules was observed (yellow modules). Comparison between HC and Ext conditions revealed several shared gene modules (yellow), particularly in NAc-core (top-right panel). Inner and outer rings of the sunburst plots are referred to as parent and child modules, respectively. B, C ARACNE plots showing gene network and connectivity within some of the overlapping modules across WD/Ext conditions and NAc-subregions. The colors of symbols represent module assignment. These networks also highlight hub/driver and other highly connected genes; symbols reflect hub drivers versus connected genes (triangle = hub gene; circle = gene).

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