Fig. 6: In vivo biocompatibility and wound closure of PLGA, silk, and DKBF sutures. | Nature Communications

Fig. 6: In vivo biocompatibility and wound closure of PLGA, silk, and DKBF sutures.

From: Chain entanglement enhanced strong and tough wool keratin/albumin fibers for bioabsorbable and immunocompatible surgical sutures

Fig. 6

a Schematic illustration of the subcutaneous implantation of sutures in C57BL/6 mice. Degradability was assessed on days 3, 7, and 14, while inflammation and tissue regeneration were evaluated on day 7. b Digital photographs of the sutures at various time points following subcutaneous implantation. c Hematoxylin and eosin (H&E) and Masson’s trichrome (M&T) stained histological sections of excised tissues on day 7 (n = 3 mice per group). Asterisks (*) in the section images indicate the original locations of the implants. Red arrows in the section images point to the foreign body giant cells. d Schematic illustration of incision wounds closed with PLGA, silk, and DKBF sutures. e Images of wounds stitched with PLGA, silk, and DKBF sutures on day 1 and day 7. f H&E staining of wound tissues stitched with different sutures on day 7 (n  =  3 mice per group). The dotted lines in the section images mark the location of the healed wound. Note: a and d are created in BioRender. Ji, J. (2025) https://BioRender.com/w03w579.

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