Fig. 1: Isolation and characterization of the M1R and B6R antibodies. | Nature Communications

Fig. 1: Isolation and characterization of the M1R and B6R antibodies.

From: Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus

Fig. 1

A Diagram of the EV and MV forms of MPXV. M1R and B6R are located on the surface of the mature and enveloped virions, respectively. B and C Frequency distribution of human IGVH and IGVL in M1R (B) and B6R antibodies (C). D The length of the CDR3 at IGVH and IGVL in M1R and B6R antibodies. (E) Binding activity and neutralization potency of the M1R and B6R antibodies. The binding assay was based on ELISA while the neutralizing activity was measured using replication-deficient MPXV. The number in the box indicates the half-maximal effective concentration (EC50) or half-maximal inhibitory concentration (IC50) values. Blank or excluded values were represent by an X in the corresponding table cells. No detective (N.D.) indicates that no response was observed at the highest concentration, while > 1000 or > 66.7 denotes that the EC50 or IC50 value of the antibody is higher than the maximum detectable concentration. Binding and neutralization curves are shown in Figure S2. Source data are provided as a Source Data file.

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