Fig. 5: In vivo hemostasis of hemorrhaging liver injury in rats and hemodilution-induced coagulopathic pigs. | Nature Communications

Fig. 5: In vivo hemostasis of hemorrhaging liver injury in rats and hemodilution-induced coagulopathic pigs.

From: Covalently reactive microparticles imbibe blood to form fortified clots for rapid hemostasis and prevention of rebleeding

Fig. 5

a Schematic illustration of hemostasis using oHA microparticles in a rat liver injury model. Created in BioRender. Chen, T. (2025) https://BioRender.com/s64m575. b–d Hemostatic performance of gauze, Arista, Surgicel, Quikclot, Gelfoam + T, and BICMs. Representative photographs (b), time to hemostasis (c), and blood loss (d) during liver bleeding or hemostasis. e Representative histological images with H&E staining of injured livers, and the thickness of the fibrotic capsule 1 week post-injury. Dashed lines indicate the boundaries between the liver tissue (L), the fibrotic capsule (F), and the injury site (I). f Schematic illustration of the hemorrhaging liver injury model in hemodilution-induced coagulopathic pigs. Created in BioRender. Chen, T. (2025) https://BioRender.com/w64h091. g, h Time to hemostasis (g) and blood loss (h) during hemostasis in the BICMs and Surgicel groups (12 injuries in three pigs, n = 8 for BICMs and n = 4 for Surgicel). Blood loss was determined as the weight gain of gauze covering the hemostats. i Representative photographs during liver bleeding or hemostasis. j Representative histology images with H&E staining of injured livers 1-day post-injury. Data are presented as means ± s.d., and all statistical analyses were performed using an unpaired two-tailed Student t test. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. Source data are provided as a Source Data file.

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