Fig. 1: Photomorpholino used for light-induced protein expression. | Nature Communications

Fig. 1: Photomorpholino used for light-induced protein expression.

From: Optochemical control over mRNA translation by photocaged phosphorodiamidate morpholino oligonucleotides in vivo

Fig. 1

cPMO is a photocaged morpholino oligonucleotide where three photocaging groups are attached (pink color), and the morpholino unit is linked by a phosphorodiamidate linkage (pink lines, -), and also a regular cytidine is replaced by C5 phenylacetylene–modified cytidine. In cPMO2, the first four linkages are replaced by guanidinum (pink circumflex, ^), and the rest of the linkages constitute the phosphorodiamidate backbone. Translation-blocking morpholino sequence: 5’-CCTCTTACCTCAGTTACAATTTATA-3’ (tbMO).

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