Fig. 1: Overall architecture of VUF11418-bound, VUF10661-bound, and Apo-CXCR3-G-protein complexes. | Nature Communications

Fig. 1: Overall architecture of VUF11418-bound, VUF10661-bound, and Apo-CXCR3-G-protein complexes.

From: Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system

Fig. 1

a, b Chemical structure of VUF11418 (a) and VUF10661 (b). Chemical structures have been prepared using Marvin JS. c–e Map and ribbon diagram of the ligand-bound and Apo-CXCR3-Go complexes (front view) and the cryo-EM densities of the ligands (sticks) are depicted as transparent surface representations. (VUF11418-CXCR3: pale violet red, VUF11418: deep teal, VUF10661-CXCR3: olive drab, VUF10661: cyan, Apo-CXCR3: dark goldenrod, miniGαo: cornflower blue, Gβ1: light coral, Gɣ2: chartreuse, scFv16: gray).

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