Fig. 2: NM102 affinity to Mfd. | Nature Communications

Fig. 2: NM102 affinity to Mfd.

From: An anti-virulence drug targeting the evolvability protein Mfd protects against infections with antimicrobial resistant ESKAPE pathogens

Fig. 2

A ITC measurement of binding of NM102 to Mfd. The heat rate in the presence of NM102 was compared with and without NM102 and plotted as a function of time (higher panel), and the normalized fit was measured with an increased mole ratio (lower panel). B ITC thermodynamic parameters associated with the interaction of Mfd with ATP in the absence or presence of NM102. Kd, dissociation constant Kd, Ka, association constant, A, ratio of Ka in the presence vs absence of inhibitor NM102.

Back to article page