Fig. 4: Different conformations of EBOV polymerase complexes. | Nature Communications

Fig. 4: Different conformations of EBOV polymerase complexes.

From: Structural insights into the RNA-dependent RNA polymerase complexes from highly pathogenic Marburg and Ebola viruses

Fig. 4

a, b, f Structural comparisons of the EBOV polymerase from this study with previously published structures (PDB: 7YES, 7YER and 8JSL) based on the alignment of the palm subdomains. The EBOL model from this study is color-coded by (sub)domains: NTD (slate), fingers (blue), palm (red), thumb (green), and PRNTase (cyan). The previously published EBOV polymerase structures (PDB: 7YES, 7YER and 8JSL) are colored in pink, light blue and gray, respectively. Relative rotation angles and translation distances of each (sub)domain are indicated. c–e, g Central cavity spaces of EBOV polymerases are visualized as wheat-colored volumes. h–k Close-up views of the promoter RNA entry channels in the EBOV polymerase structures are visualized as wheat-colored volumes.

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