Fig. 3: Architecture of the GCase/LIMP-2 complex.
From: Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2
A Model of sLIMP-2 (blue) and GCase (orange) in complex (cartoon style). Magnified view of the binding interface shows helix 5 and 7 on LIMP-2 and helix 1 and 3 as well as loops A, B, C and D on GCase as mediators of interaction (colored in red). B GCase/LIMP-2 complex (surface style) with key features and binding interfaces colored and annotated. Left side highlights GCase (orange) with active side cavity (green) and LIMP-2 interface (red). Right side highlights LIMP-2 (blue) with cholesterol transport channel indicated (brown) GCase binding interface (purple) and proposed pH-switch His171 (yellow). The hypothesized orientation of the complex at the membrane is illustrated.
