Fig. 2: Structures and locations of γ and δ subunits.
From: Molecular basis for the regulation of human phosphorylase kinase by phosphorylation and Ca2+
a Overall structure of the γδ complex. Left, the location of γ and δ subunits in one protomer of hPhK. Right, an enlarge view of the γδ complex. The γ-CKD, γ-CBD, and γ-AID regions are represented by cornflower blue, blue, and dark cyan, respectively, while the δ-subunit is represented by orange. The γ-CKD region consists of the N-lobe and C-lobe. b Interactions between the γ-AID region and γ-CKD region. Dotted lines correspond to putative hydrogen bonds. c Overlap the structure of CKD region of rPhKγ (PDB ID: 2PHK, with ATP and MC peptide) with hPhKγ. G360, K361, and K362 from the AID region of hPhKγ conflict with the MC peptide. The hPhKγ is colored the same as (a), and the rPhKγ is colored by light gray and black. d Conserved surface mapping of δ subunit (CaM) using ConSurf. e Overall structure of CaM and γ-CBD region. f Interactions between CaM and C lobe of γ-CKD region.
