Fig. 2: Concurrent IFNα and IL-12 expression increases MHC-I and MHC-II presentation in liver metastases.
From: In vivo armed macrophages curb liver metastasis through tumor-reactive T-cell rejuvenation
A, B UMAP projection of single-cell RNA sequencing (scRNA-seq) data obtained from CD45+ cells sorted from a healthy liver lobule (A) or a matched liver metastasis (B) from mice treated with IiOVA, OVA.Ifna, OVA.Il12 or OVA.Combo (n = 2, 3, 3, 3 mice/group for IiOVA, OVA.Ifna, OVA.Il12, and OVA.Combo, respectively). C, D UMAP projection of scRNA-seq of APC subcluster for the indicated tissues. E, F Fraction of positive cells and scaled averaged expression of selected genes belonging to the indicated biological processes in the APCs from indicated tissues (n = 2, 3, 3, 3 mice/group for IiOVA, OVA.Ifna, OVA.Il12, and OVA.Combo). G Combined gene expression score for genes belonging to the indicated categories in the distinct liver myeloid populations.
