Fig. 9: Models illustrating how PACT and ADAR1 establish a threshold for tolerable dsRNA levels to prevent PKR activation. | Nature Communications

Fig. 9: Models illustrating how PACT and ADAR1 establish a threshold for tolerable dsRNA levels to prevent PKR activation.

From: Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA

Fig. 9

PACT and ADAR1 collaborate to maintain a threshold of tolerable dsRNA levels, allowing cells to manage self-dsRNA without triggering PKR-mediated translation shutdown and cell death. During viral infection, however, the increased levels of dsRNA exceed the protective threshold set by PACT and ADAR1, leading to PKR activation. Either PACT or ADAR1 alone is sufficient to sustain this threshold, preventing self-dsRNA from activating PKR. Conversely, simultaneous loss of both PACT and ADAR1 results in uncontrolled PKR activation, causing rapid cell death. Created in BioRender. Buisson, R. (2025) https://BioRender.com/o10z759.

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