Fig. 2: Summary of significant association findings. | Nature Communications

Fig. 2: Summary of significant association findings.

From: Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele

Fig. 2

A Manhattan plot of multi-population, single-variant analysis (N = 88,873 individuals). The novel locus (MTMR3) is highlighted in red. Previously reported BMI loci are in dark beige. The horizontal dashed line indicates the genome-wide significance threshold two-sided P = 5 × 10−9, to account for multiple testing. B Scatterplot showing the minor allele frequency compared to the absolute value of the estimated effect of the index variant at each significant locus. All effect estimates are from the primary analysis conducted across all population groups. Previously reported loci are highlighted in blue, while the novel locus is in red; circles represent the most significant variant at each locus, and triangles show newly reported secondary signals within known loci.

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