Fig. 2: X-ray crystal structure of IZKF2:CRBN:compound 5 ternary complex. | Nature Communications

Fig. 2: X-ray crystal structure of IZKF2:CRBN:compound 5 ternary complex.

From: Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy

Fig. 2

a Ternary structure of IKZF2 Zinc finger 2 (ZF2) domain (green) with CRBN Thalidomide-binding domain (TBD, gray) and compound 5 (yellow sticks) at 1.7 Å resolution (PDB ID: 9DOM). b Detailed interactions of IKZF2:CRBN:Compound 5 ternary structure with hydrogen bonds shown in dashed lines.

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