Table 3 Adverse events in neoadjuvant therapy and surgery
Type of event | No. of Participants | ||
|---|---|---|---|
Grades 1-4 (%) | Grade 3-4 (%) | SAE (%) | |
Adverse Event (n = 51) | 49 (96.1) | 5 (9.8) | 4 (7.8) |
Fatigue | 25 (49.0) | 0 | 0 |
ALT elevation | 20 (39.2) | 1 (2.0) | 1 (2.0) |
Rash | 18 (35.3) | 0 | 0 |
Hyponatremia | 14 (27.5) | 0 | 0 |
Acrodynia | 12 (23.5) | 0 | 0 |
Stomatitis | 11 (21.6) | 0 | 0 |
Thrombocytopenia | 11 (21.6) | 0 | 0 |
AST elevation | 10 (19.6) | 1 (2.0) | 0 |
Hyperglycemia | 8 (15.7) | 0 | 0 |
Diarrhea | 6 (11.8) | 0 | 0 |
Creatinine elevation | 5 (9.8) | 0 | 0 |
Chest pain | 5 (9.8) | 0 | 0 |
Neutropenia | 4 (7.8) | 0 | 0 |
Blood bilirubin elevation | 4 (7.8) | 0 | 0 |
Stomachache | 3 (5.9) | 0 | 0 |
Anemia | 3 (5.9) | 0 | 0 |
Nausea | 3 (5.9) | 0 | 0 |
Pruritus | 3 (5.9) | 0 | 0 |
Pneumonia | 2 (3.9) | 1 (2.0) | 1 (2.0) |
Abdominal pain | 2 (3.9) | 0 | 0 |
Abdominal distension | 2 (3.9) | 0 | 0 |
Headache | 2 (3.9) | 0 | 0 |
Toothache | 2 (3.9) | 0 | 0 |
Lymphopenia | 2 (3.9) | 0 | 0 |
Lightheadedness | 2 (3.9) | 0 | 0 |
Constipation | 2 (3.9) | 0 | 0 |
Hyperuricemia | 2 (3.9) | 0 | 0 |
Thromboembolic event | 1 (2.0) | 1 (2.0) | 1 (2.0) |
Ischemia cerebrovascular | 1 (2.0) | 1 (2.0) | 1 (2.0) |
Hyperpotassemia | 1 (2.0) | 0 | 0 |
Hypercalcemia | 1 (2.0) | 0 | 0 |
Urinary tract infection | 1 (2.0) | 0 | 0 |
Arrhythmia | 1 (2.0) | 0 | 0 |
Anorexia | 1 (2.0) | 0 | 0 |
Surgical-Related Complications (n = 23) | |||
Bronchopleural Fistula | 1 (4.3) | 0 | 0 |
