Fig. 5: EGFR inhibition represses ccRCC cell progression in vitro and in vivo. | Nature Communications

Fig. 5: EGFR inhibition represses ccRCC cell progression in vitro and in vivo.

From: Identifying potential risk genes for clear cell renal cell carcinoma with deep reinforcement learning

Fig. 5

A Erlotinib markedly promoted apoptosis and inhibited migration and colony formation of ccRCC cells. n = 3 independent experiments. B, C Both erlotinib (B) (n = 3 mice per group) and EGFR knockdown (C) (n = 3 mice per group) significantly reduced tumor growth in vivo. The data were shown as the mean  ± SEM. Two-tailed unpaired Student’s t-test (A). Two-way ANOVA (B, C). Source data are provided as a Source Data file.

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