Fig. 2: Crystal structure of calcium-activated hEndoU.
From: Molecular basis for the calcium-dependent activation of the ribonuclease EndoU
A Overview of calcium-activated hEndoU structure. Calcium binding sites (1)–(4) as referred in the text are indicated. B Closeup view of hEndoU calcium binding sites. Residues from the catalytic core (white) and from the N-terminal extension (blue) are highlighted. C Intramolecular signaling between calcium binding site (1) and remote catalytic residues. Catalytic residue (yellow) are highlighted, along with residues from the catalytic core (white) and from the N-terminal extension (blue). D Structural change upon hEndoU allosteric activation by calcium. For (A–D), the calcium-binding sites are labeled with numbers in parentheses (black).
