Fig. 2: Overview of derived datasets in the Estonian Biobank.

A CNVs in the EstBB cohort. Deletion (blue) and duplication (yellow) frequencies (y-axis) at GSA probe positions (x-axis) are presented. The dashed line indicates 1% frequency. Loci with CNV frequencies >5% are labelled with cytogenic bands. B Numbers of detected CNVs (x-axis) with copy number 0 to 4 (y-axis). C Number of individuals (y-axis) and frequencies of assessed pharmacogenetic phenotypes of nine major pharmacogenes (x-axis). The proportions of PGx phenotypes among all analysed individuals (N = 211,257) are shown with percentages on each bar. Different colours correspond to the established PGx phenotypes for each gene. D Observed number of microbial species (y-axis) among the microbiome cohort participants who had taken 0, 1–5 or >5 courses of antibiotics within 5 years prior to microbiome sample collection. Individuals who used antibiotics within 6 months before sampling were excluded.