Fig. 5: Model for PA14-infection-induced behavioral changes in C. elegans. | Nature Communications

Fig. 5: Model for PA14-infection-induced behavioral changes in C. elegans.

From: Pathogen infection induces sickness behaviors through neuromodulators linked to stress and satiety in C. elegans

Fig. 5

Neuromodulatory pathways associated with stress (blue panel, left) and satiety (yellow panel, right) are recruited upon infection to drive changes in feeding and quiescence upon infection. Upon heat shock, the ALA neuron induces quiescence through the action of its neuropeptides, including the FMRFamide peptide FLP-13 (red rectangle)20,22 and via the neuron RIS48,49. In satiated animals, the neuromodulator TGF-beta/DAF-7 is released by the ASI neurons to promote quiescence. These neuromodulatory pathways are recruited in the infection context (center panel). While ALA continues to suppress behaviors like feeding, FLP-13 delays quiescence and is released from other neurons (red circles). The effects of FLP-13 to delay quiescence are suppressed by the quiescence-promoting ASI and TGF-beta/DAF-7 pathway.

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