Table 1 IC50 values [nM] for Sulphostin and the reference compounds VbP, 1G244 and 4OβL-6 inhibiting DPP4/8/9

From: Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors

 

IC50 [nM]

Compounds

DPP4

DPP8

DPP9

Sulphostin

79 ± 29

6930 ± 620

1392 ± 108

VbP

8.3 ± 0.9

1.7 ± 0.1

1.3 ± 0.1

1G244

>100,000

4.4 ± 1.5

14 ± 2

4OβL-6

8354 ± 728

582 ± 36

1180 ± 102

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