Fig. 2: Baseline and cytokine responses in aged patients after ICI exposure is unique from young patients. | Nature Communications

Fig. 2: Baseline and cytokine responses in aged patients after ICI exposure is unique from young patients.

From: Age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors

Fig. 2

A Senescence associated secretory phenotype (SASP)-related cytokines at baseline (aged, n = 54; young, n = 50). B Heatmap visualization of log2 transformed fold change of 32 cytokines for patients stratified by age group after start of immune checkpoint inhibitor (ICI) treatment (aged, n = 50; young, n = 45). C Cytokines with statistically different levels between age groups for log2 transformed fold change after ICI treatment (aged, n = 50; young, n = 45). In (A, C), the box and whisker plots show the median, interquartile range (IQR), minimum/maximum values, and additional marking of outliers. Statistical comparisons between quantitative measurements were performed using a two-sided Wilcoxon rank-sum test without adjustment for multiple comparisons. Source data are provided as a Source Data file.

Back to article page