Fig. 6: Analysis of integrated cytokine and cellular immune profiles in young and aged patients treated with ICI therapy. | Nature Communications

Fig. 6: Analysis of integrated cytokine and cellular immune profiles in young and aged patients treated with ICI therapy.

From: Age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors

Fig. 6

Principal component (PC) analysis of low-dimensional representations of immune profiles performed by integrating available cytokine and immune cell type abundance data on a per patient basis across the clinical cohort (n = 17 aged responders, 29 aged non-responders, 8 young responders, 24 young non-responders for (A, B) and n = 17 aged responders, 28 aged non-responders, 8 young responders, and 24 young non-responders for (C, D). Patients without annotated clinical responses were not included in this analysis. Differences in average component scores were evaluated to identify the two principal axes that best facilitated comparisons based on age or response. Plots are presented baseline (A, B) and first on treatment (C, D) and for PCs for either age (left side) or immune checkpoint inhibitor (ICI) response status (right side). Source data are provided as a Source Data file.

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