Fig. 1: Antibiotic-induced microbiota alterations impact pregnancy outcome. | Nature Communications

Fig. 1: Antibiotic-induced microbiota alterations impact pregnancy outcome.

From: Maternal gut microbiota influences immune activation at the maternal-fetal interface affecting pregnancy outcome

Fig. 1

Schematic representation of the experimental plan (a). Vancomycin treatment (filled symbols) is associated with increased pregnancy loss and fetal resorption at embryonic day (ed) 12.5 (p = 0.0259) and ed14.5 (p = 0.0003) (b, c), significant reduction of placental/fetal ratio at ed14.5 (p = 0.0115, placental weight on fetal weight, d), reduction of the labyrinth area (p = 0.0052, e, f) and increased blood engorgement (g) compared to control pregnancies (open symbols) at ed14.5. Lines represent mean plus SEM, two-sided Mann Whitney test *p < 0.05, **p < 0.01, ***p < 0.001 (c–e). Magnification: 10X (f, g). ed: embryonic day; Lab: labyrinth. c includes 10 independent experiments. d represents 9 independent experiments for control and vamcomycin-treated dams at ed12.5, 10 independent experiments for control and vancomycin-treated dams at ed14.5, and 10 independent experiments for control dams and 7 independent experiments for vancomycin-treated dams at ed18.5. In (e), 10 different placentas isolated from 5 experiments were measured. See also Supplementary Fig. 1. Source data are provided as a Source Data file.

Back to article page