Fig. 6: In silico inhalation study of PRS-220 in 3 human subjects shows a broad deposition pattern of PRS-220 containing aerosol in healthy and IPF lungs. | Nature Communications

Fig. 6: In silico inhalation study of PRS-220 in 3 human subjects shows a broad deposition pattern of PRS-220 containing aerosol in healthy and IPF lungs.

From: Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment

Fig. 6

a CT image analysis and segmentation of fibrotic tissue (red) and b airways, lungs, and lobes (left) as first step of the subject-specific model generation process. Generation of the full 16-generation tree of conducting airways (right) and viscoelastic alveolar clusters (Supplementary Fig. 4) based on segmented volumetric information and a physiology-based, space-filling growth algorithm. c Final pattern of deposited PRS-220 aerosol particles after simulation of airflow, particle transport and deposition for one complete breathing cycle. d Mass fraction of deposited aerosol per category: Mouth/throat (green), conducting airways (orange), alveolar tissue (blue), and exhaled (brown). e Normalized concentration of deposited aerosol mass per volume for healthy vs. fibrotic regions of the lungs (mild case = orange; severe case = red). Values smaller/>100% indicate under/over-proportional deposition in the respective sub-volume.

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