Fig. 9: Prediction of three-way chromatin interactions based on Tensor-FLAMINGO’s predicted 3D chromatin structures. | Nature Communications

Fig. 9: Prediction of three-way chromatin interactions based on Tensor-FLAMINGO’s predicted 3D chromatin structures.

From: Tensor-FLAMINGO unravels the complexity of single-cell spatial architectures of genomes at high-resolution

Fig. 9

a Three-way chromatin interactions are predicted from the 3D chromatin structures by evaluating the set of pairwise 3D distances. b Predicted three-way chromatin interactions at 10kb-resolution are supported by single-cell SPRITE (scSPRITE) data (the number of predicted three-way interactions n = 3408, p-value = 1.4 × 10−5, one-sided Mann-Whitney U test). Higher scSPRITE scores suggest that the predicted three-way interactions are observed in more single cells in the scSPRITE dataset. The center lines of boxplots show the median; the upper and lower box limits show the 25th and 75th percentiles, respectively. The whiskers extend up to 1.5 times the interquartile range away from the limits of the boxes. c Example of the predicted three-way interactions supported by the scSPRITE cluster at the same genomic location. The anchors of the predicted three-way interaction align with the hotspots from the scSPRITE data. d Example of the group-specific single-cell 3D chromatin structures and group-specific single-cell three-way interactions. Source data are provided as a Source Data file.

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