Fig. 3: Gene-set analysis for Breast Cancer, estimated using MAGMA, for GWAS and WGWAS, across 54 gene sets. | Nature Communications

Fig. 3: Gene-set analysis for Breast Cancer, estimated using MAGMA, for GWAS and WGWAS, across 54 gene sets.

From: Correcting for volunteer bias in GWAS increases SNP effect sizes and heritability estimates

Fig. 3

Panel (a) displays the results as estimated by GWAS. Panel (b) displays the results as estimated by WGWAS. Only the 15 gene sets with the lowest p-value are included in the plots. The dotted horizontal line denotes the 5% Bonferroni-corrected significance level (correction for 54 hypotheses). P-values were calculated using a one-sided test, where the null hypothesis states that the gene set does not exhibit above-average expression for the trait.

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