Table 2 Comparison of weighted and unweighted GWAS results
From: Correcting for volunteer bias in GWAS increases SNP effect sizes and heritability estimates
(1) | (2) | (3) | (4) | (5) | (6) | (7) | (8) | |
|---|---|---|---|---|---|---|---|---|
Phenotype | r | \({N}_{eff}^{GWAS}\) | \({N}_{eff}^{WGWAS}\) | Increase S.E.s | sig. hits GWAS | sig. hits WGWAS | unique hits WGWAS | New loci |
Age at First Birth | 0.976 (0.013) | 139,093 | 51,949 | 71% | 30 | 3 | 2 | 0 |
BMI | 0.992 (0.005) | 372,969 | 135,238 | 77% | 1205 | 127 | 5 | 0 |
Breast cancer | 0.803*(0.038) | 197,857 | 90,492 | 40% | 45 | 8 | 4 | 1 |
Drinks per Week | 0.936*(0.019) | 265,696 | 96,008 | 83% | 23 | 4 | 0 | 0 |
Self-rated health | 0.973*(0.009) | 372,714 | 136,982 | 82% | 101 | 6 | 0 | 0 |
Height | 0.993 (0.003) | 374,175 | 151,328 | 61% | 5114 | 1453 | 22 | 0 |
Physical activity | 0.866*(0.031) | 334,570 | 123,017 | 75% | 3 | 0 | 0 | 0 |
Severe Obesity | 0.949*(0.018) | 373,834 | 136,396 | 75% | 23 | 1 | 0 | 0 |
Type 1 Diabetes | 0.660*(0.057) | 373,786 | 132,605 | 87% | 69 | 37 | 15 | 3 |
Years of Education | 0.988 (0.006) | 392,433 | 160,707 | 64% | 331 | 49 | 3 | 0 |
