Fig. 1: Structures of Htt exon 1, curcumin and Thioflavin T (ThT). | Nature Communications

Fig. 1: Structures of Htt exon 1, curcumin and Thioflavin T (ThT).

From: Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates fibril-induced cellular stress

Fig. 1

a Domain structure of HttEx1, showing the central polyQ segment (blue) as well as the N-terminal (httNT; orange) and C-terminal flanking segments (proline-rich domain; PRD; green). b Model of the previously determined fibril architecture of Q44-HttEx1 forming single-filament fibrils. Indicated domains: httNT (orange; α-helix), polyQ (red and blue; β-sheet), and PRD (green; PPII helices). c Chemical structures of curcumin and (d) Thioflavin T. Panel b was adapted from ref. 19 under its CC open-access license.

Back to article page