Fig. 2: EAE mice harbor two distinct C3+ microglial populations including a MIMS-like phenotype that is enriched in lysosomal clearance pathways. | Nature Communications

Fig. 2: EAE mice harbor two distinct C3+ microglial populations including a MIMS-like phenotype that is enriched in lysosomal clearance pathways.

From: Myeloid lineage C3 induces reactive gliosis and neuronal stress during CNS inflammation

Fig. 2

a Violin graphs showing expression of 16 MIMS markers in C3-tdTomato+ (orange) and C3-tdTomato− (blue) microglia. N = 3 samples. Asterisks next to the gene name denotes that comparison has FDR < 0.05. FDR value derived from pseudobulk differential expression test with edgeR. b Violin graphs showing the 16 canonical MIMS markers broken down over each microglial subcluster. Orange clusters are the two C3+ tdTomato+ clusters. c Panel of selected markers for cluster 3 and cluster 5. d, e GSEA indicating directionality of pathways in cluster 3 and 5 respectively. Pathways that peak on the left are upregulated in that cluster. Normalized Enrichment Score is included in parentheses after the pathway name.

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