Fig. 5: Heatmap displaying the correlation coefficients between differentially expressed proteins (DEPs) and MR imaging metrics of glymphatic and mLV flow. ROImLVs were calculated from BB imaging, whereas PSCmLVs and FlowmLVs were derived from IR-ALADDIN imaging.

The P values were calculated using the two-sided Spearman’s correlation test. Asterisks indicate statistical significance of P < 0.05. The raw data of mass spectrometry proteomics have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD058255. mLV meningeal lymphatic vessels, PSC percent signal change, ROI region-of-interest.