Fig. 3: GWAS and genome-scale CRISPR screens provide complimentary approaches to identify regulators of erythropoiesis.
From: A genome-wide screen identifies genes required for erythroid differentiation
A Number of candidate genes nominated to have a role in erythropoiesis by either GWAS or the CRISPR knock-out screen performed in HUDEP-2 cells. ES Enrichment Score. B Number of genes identified in the CRISPR screen as erythroid essential (EE) or required for differentiation (RD), and their distributions among common essential genes, GWAS-nominated genes, and others. Shared genes denotes genes that are both common essential and nominated by GWAS. Data shown at 2 statistical cutoffs: FDR < 0.05 and FDR < 0.01 + log2-fold change < -1.
