Fig. 4: Enrichment analysis of human longevity-associated sites.

a Pathway enrichment analysis of R-to-K replacement sites (hypergeometric test and Benjamini–Hochberg p-value correction by Metascape) and b their DNA repair corresponding MCODE clusters identified from PPI networks. c Pathway enrichment analysis of Q-to-K replacement sites using Metascape. d CC analysis of R-to-K (green) and Q-to-K (blue), based on Gene Ontology (GO) annotations. e Pathway enrichment analysis of R-to-K DNA metabolic processes and f their corresponding DNA repair MCODE clusters identified from PPI networks.