Fig. 3: Fine-mapping results for KSD by using MeSuSiE and SuSiE. | Nature Communications

Fig. 3: Fine-mapping results for KSD by using MeSuSiE and SuSiE.

From: Trans-ancestry GWAS identifies 59 loci and improves risk prediction and fine-mapping for kidney stone disease

Fig. 3

A Box plot of SNP number of credible sets identified by MeSuSiE and SuSiE. The central line, bounds of box and whiskers represented to the median value, quartiles and the minima and maxima, respectively. Source data are provided as a Source Data file. B Bar plot of the number of causal signals with PIP > 0.5 detected by MeSuSiE and SuSiE. Source data are provided as a Source Data file. C LocusZoom plot displayed the fine-mapping results on KSD from different methods in a genomic region on chromosome 5. The left column showed Manhattan plots of EUR, EAS and trans-ancestry GWAS meta-analyses results in this region. The genome-wide significance threshold was 5 × 10-8, indicated by the black dashed lines. The most significant signal in EUR and EAS populations was labeled. The right column showed LocusZoom plots, displaying the PIP of signals calculated by SuSiE in EUR and EAS populations and by MeSuSiE. The last row showed annotated genes in this genomic region. For the signals in the detected credible sets, we used an upper triangle to represent a European-specific signal, a lower triangle to represent an East Asian ancestry-specific signal and a diamond to represent a shared signal. PIP of 0.5 indicated a potential causal signal, whether shared or ancestry-specific. PIP posterior inclusion probability, EUR European, EAS East Asian.

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