Table 1 The five top common virulence factors across clonal and atypical Toxoplasma strains

From: GRA12 is a common virulence factor across Toxoplasma gondii strains and mouse subspecies

   

VAND

RH

PRU

VEG

Rank

Gene

Code

L2FC in vivo

DISCO

L2FC in vivo

DISCO

L2FC in vivo

DISCO

L2FC in vivo

DISCO

1

GRA12

_288650

−3.20

26.04

−2.66

10.73

−4.82

17.71

−4.11

5.87

2

GRA45

_316250

−2.75

4.55

−2.52

4.01

−1.75

4.89

−5.25 (1)*

5.25*

3

GRA61

_269950

−2.67

9.52

−0.41

0.36

−5.77

15.77

−3.70 (2)*

4.11*

4

GRA50

_203600

−1.84

7.08

0.32

1.72

−0.21

3.53

−2.47 (2)*

4.31*

5

GRA23

_297880

−2.01

5.66

−1.64

2.10

−0.16

0.42

−3.93 (1)*

8.50*

  1. Genes were ranked based on the difference between the median L2FC in vivo and in vitro across all strains. The median L2FC in vivo and the DISCO score are reported for the five top hits. For the VEG screen numbers are reported also from the quantification with relaxed selection (>=1 guide/ gene). Values obtained only with relaxed selection are indicated with an asterisk, with the number of guides used for quantification in brackets.
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