Table 1 Voltage-dependence parameters of CaV2.1 pore opening and VSD activation

From: A rich conformational palette underlies human CaV2.1-channel availability

 

WT

VSD-I

VSD-III

VSD-IV

 

Itail(V)

Itail(V)

ΔF(V)

Itail(V)

ΔF(V)

Itail(V)

ΔF(V)

V0.5,F1 (mV)

−2.2 ± 0.86

2.0 ± 1.1

3.1 ± 1.0

−3.0 ± 1.4

−65 ± 3.8

−2.0 ± 1.0

−64 ± 6.3

zF1 (e0)

2.9 ± 0.091

3.6 ± 0.11

3.0 ± 0.39

2.5 ± 0.16

1.1 ± 0.053

3.5 ± 0.15

0.45 ± 0.017

F1 (%)

N/A

N/A

54 ± 3.9

N/A

100

N/A

100

V0.5,F2 (mV)

N/A

N/A

−120 ± 2.7

N/A

N/A

N/A

N/A

zF2 (e0)

N/A

N/A

2.8 ± 0.32

N/A

N/A

N/A

N/A

n (cells)

12

4

4

7

7

6

6

  1. Representative traces and curves in Fig. 2. Errors are S.E.M.
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