Fig. 2: cis-pQTL and T1D colocalizing signals.
From: Genetics of circulating proteins in newborn babies at high risk of type 1 diabetes
LocusZoom plots of colocalized proteins for CTRB1, APOBR and IL7R. The top panels show pQTL p-values, while the bottom panels show T1D GWAS p-values for the same regions for the colocalizing regions. Two independent T1D signals reside in the cis-region near the APOBR transcription start site, with lead variants rs34835 and rs231972. Each T1D signal (in the +/− 1 Mb window) was conditioned against the other using GCTA-COJO. The summary statistics from the conditional analysis were then used for colocalization. Only rs34835, conditioned on rs231972, showed evidence of colocalization and the corresponding PP4 is reported in the figure.
