Table 1 Mendelian randomization results for T1D colocalized signals

From: Genetics of circulating proteins in newborn babies at high risk of type 1 diabetes

Protein

SNP

Beta

SE

p-value

Adjusted p-value

CTRB1

16:75234872_rs72802342_A_C

−0.17

0.02

3.3E-19

1.7E-18

APOBR

16:28507644_rs180743_G_C

0.11

0.01

1.7E-14

8.6E-14

IL7R

5:35874575_rs6897932_T_C

0.18

0.04

3.4E-07

1.7E-06

CPA1

16:75234872_rs72802342_A_C

−0.32

0.04

3.3E-19

1.7E-18

PNLIPRP1

16:75234872_rs72802342_A_C

−0.41

0.05

3.3E-19

1.7E-18

  1. Results of the two-sample MR analysis using the lead pQTL as instrumental variable, protein levels as exposure and T1D (GWAS Catalog accession number GCST90014023) as outcome. The effect size (beta) represents the T1D risk per one standard deviation of the genetically predicted protein levels. Bonferroni adjustment was used to correct the p-values. SNP single nucleotide polymorphism, SE standard error
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