Fig. 3: Conformational changes in MED23 upon Elk-1 binding.
From: Structural basis of human Mediator recruitment by the phosphorylated transcription factor Elk-1
Overlay of MED23 (in dark gray) and MED23Elk-1 (in light coral) structures in cartoon representation highlighting MED23 conformational changes upon Elk-1 binding. a Relative movement observed for MED23 HR2 domain residues 403–501. b MED23 501-516 segment located at the HR2-HR3 junction is disordered in MED23Elk-1 complex. c Global movement of helix H19 in HR2. d Density differences reflecting HR4-lid conformational changes between MED23 and MED23Elk-1. The map-model fit of MED23 1019–1081 (in gray) and MED23Elk-1 (in light coral) in surface representation. Side chains are represented in stick. Side chains of MED23 H56 were omitted for clarity. The 1019–1081 sequence is indicated (helices H54 to H56), with the HR4-lid sequence 1033–1052 underlined in bold.
