Fig. 3: Phenotypic follow up of the identified sd-pQTLs with 365 disease outcomes with more than 2500 cases in UK Biobank.
From: Sex differences in the genetic regulation of the human plasma proteome
Logistic regression models were used to calculate associations between genetic variants and disease outcomes in each sex. A Miami plot of association of 100 unique variants driving 103 sex-differential pQTLs (sd-pQTLs) with 365 disease outcomes among females on the top and among males at the bottom panel. x-axis contains each of the sd-pQTL—disease outcome pairs, ordered by their phecodes within each disease category. The associations have been coloured by disease categories. The horizontal dashed line represents a suggestive significance threshold of (p < 1 × 10−5). B Comparison of odds ratios for the sd-pQTL—disease associations which meet the suggestive significance threshold (p < 1 × 10−5) in males or females. The diagonal dashed line represents the equality line (x = y). C Comparison of −log10transformed P values for the sd-pQTL—disease associations which meet the suggestive significance threshold (p < 1 × 10−5) in males or females. The diagonal dashed line represents the equality line (x = y).
