Fig. 3: Compartmentalization of mouse and human sperm.
From: Three-dimensional genome structures of single mammalian sperm
a, b Contact correlation heatmaps showing pairwise correlations between 1-Mb regions along mouse (a) and human (b) chromosomes. Compartments A and B are classified using normalized principal component eigenvectors (E1). E1 values for mESC and GM12878 are also shown for comparison. c, d Left: cross sections of example mouse (c) and human (d) single sperm showing compartmentalization measured by scA/B values. Right: average distribution of compartmentalization shown on a cross-section of mouse (c) and human (d) sperm nucleus. e, f Cross sections showing the spatial-dependent fluctuation of compartment strength in mouse (e) and human (f) sperm. The middle 1-Mb region (50 20-kb bins) of each compartment B is selected to generate the plots. For each selected bin, the corresponding particles in different cells are ranked according to their scA/B values. The spatial position of the particles from the top 100 cells are then plotted as the “strong B particles” (left), and particles from the bottom 100 cells are plotted as the “weak B particles” (right).
