Fig. 6: Mediterranean diet restricts hematopoietic activity in individuals with MS.
From: Myelopoiesis is temporally dynamic and is regulated by lifestyle to modify multiple sclerosis
a Schematic of human diet intervention study. b Change in NFI-MS, MSIS, and EDSS by mediterranean diet (n = 13 habitual diet, n = 16 mediterranean diet). c Enumeration of circulating PBMCs in participants after 6 months on their habitual diet or the Mediterranean diet (n = 14 habitual diet, n = 17 mediterranean diet). d Flow cytometry analysis of lineage-CD34+ HSPCs. Quantification of HSPCs in MS patients after 6 months on their habitual diet or the Mediterranean diet (n = 13 habitual diet, n = 14 mediterranean diet). e Quantification of circulating CD115+ HSPCs (n = 14 habitual diet, n = 14 mediterranean diet). f Quantification of circulating CD123+ HSPCs n = 14 habitual diet, n = 15 mediterranean diet). Data presented as mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Two sided Mann Whitney U tests. Created in BioRender. McAlpine, C. (2025) https://BioRender.com/kvggmpp. MS multiple sclerosis, LDL low density lipoprotein, BMI body mass index, NFI-MS neurological fatigue index-multiple sclerosis, MSIS multiple sclerosis impact scale, EDSS expanded disability status scale, PBMCs peripheral blood mononuclear cells, HSPCs hematopoietic stem and progenitor cells.
