Table 1 Summary statistics for rs13303010 on 1p36.33 PDAC risk locus

From: Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33

aSNP, balleles, cchr, dlocation, and egene

Study

MAF

Subjects

P-value

Allelic OR (95% CI)

Controls

Cases

Controls

Cases

rs13303010 (G, A)

2018 Meta Analysis4

  

12,496

9040

7.3 × 10−7

1.20 (1.12–1.29)

1p36.33 (894,573)

PANDoRA4

0.10

0.14

4611

2497

6.0 × 10−10

1.45 (1.33–1.57)

NOC2L

Meta Analysis + PANDoRA4

  

17,107

11,537

8.36 × 10−14

1.26 (1.19–1.35)

 

UK Biobank

0.09

0.12

9399

1066

1.05 × 10−5

1.42 (1.21–1.65)

 

Meta Analysis4 + UK Biobank

  

21,895

10,106

2.09 × 10−10

1.24 (1.16–1.32)

  1. Summary statistics from previously published PDAC GWAS and for the new meta-analysis presented here including UK Biobank PDAC cases and controls for rs13303010 including minor allele frequencies in cases and controls, P-value, and odds ratio (OR) with the 95% confidence intervals (CI). Statistics are generated using a logistic regression model adjusted for covariates outlined in the Methods. P-values are not multiple-testing corrected. Source data are provided as a Source Data file.
  2. arsID; SNP ID number.
  3. bMinor, major alleles.
  4. cLocation.
  5. dPosition (Genome build hg19).
  6. eNearest gene.
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