Fig. 4: Resolution analysis of HetSIREN map compared against the map refined from the EMPIAR 10028 dataset with CryoSparc38. | Nature Communications

Fig. 4: Resolution analysis of HetSIREN map compared against the map refined from the EMPIAR 10028 dataset with CryoSparc38.

From: Real-space heterogeneous reconstruction, refinement, and disentanglement of CryoEM conformational states with HetSIREN

Fig. 4

(a) shows first the CryoSparc refinement obtained from the 50k particle dataset processed inside Scipion (left) followed by the HetSIREN decoded map (right), both colored according to their local resolution estimated with DeepRes20. The comparison shows a significant improvement in the local resolution of the map decoded by HetSIREN. b Quantitatively compares the estimated local resolutions based on local resolutions histograms. Similarly to (a), the local resolution of HetSIREN shows a strong displacement of the voxel resolutions to the high-resolution domain, translating into an improvement of 2.7 Å in the mean resolution. Source data are provided as a Source Data file.

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