Fig. 9: Structural differences of the SARS-CoV-2 Spike protein at different temperatures. | Nature Communications

Fig. 9: Structural differences of the SARS-CoV-2 Spike protein at different temperatures.

From: Real-space heterogeneous reconstruction, refinement, and disentanglement of CryoEM conformational states with HetSIREN

Fig. 9

Representative maps of the main conformational states detected by the HetSIREN network when the Spike protein is kept at 4°C (a) or 37°C (b). At 4°C (a) the Spike always shows at least one (orange) or two (red) RBDs in its open position. At 37°C (b) the Spike is mainly detected in its 3 Down conformation (yellow), with a lower population of particles exhibiting a 1 Up state (orange).

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