Fig. 3: Viral load in tissues from rhesus macaques infected with EBOV and treated beginning 5 DPI with ZMapp, remdesivir, REGN-EB3, or mAb114.

The viral load in selected tissues sampled at necropsy was assessed by RT-qPCR amplification of EBOV vRNA. For each treatment group, treated animals were grouped by clinical outcome (“survivor” or “fatal”), while the in-study control(s) were plotted separately. a Tissue viral load in animals from the ZMapp treatment study (b) Tissue viral load in animals from the remdesivir treatment study. c Tissue viral load in animals from the REGN-EB3 treatment study. d Tissue viral load in animals from the mAb114 treatment study. Bars represent the geometric mean ± geometric SD for each group. Individual animals are represented by color-coded symbols within bars. For all panels, individual data points represent the mean of two technical replicates. Dashed horizontal lines indicate the lower limit of quantitation (LLOQ) for the assay (1000 GEq/g tissue, where GEq genome equivalents). Values below the LLOQ are plotted as 999 GEq/g tissue. Missing values indicate the given tissue was not assessed for that animal. Tissues with asterisks were only assessed for surviving animals, except in (d), where tissues were screened for a single animal (m114-1) with a delayed time to death (DDTD) of 14 DPI. Due to the small sample sizes in each cohort, statistical analysis was not performed. Abbreviations for tissues: ALN axillary lymph node, ILN inguinal lymph node, Liv liver, Spl spleen, Kid kidney, Adr adrenal gland, BrFr brain frontal cortex, BrSt brain stem, CSC cervical spinal cord, Pan pancreas, Uri urinary bladder, Gon gonad, Ut/Pro uterus/prostate, Conj conjunctiva.